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Nephrology
Usefulness of BK virus-specific interferon-γ enzyme-linked immunospot assay for predicting the outcome of BK virus infection in kidney transplant recipients
Hyunjoo Bae, Do Hyun Na, Ji-Yeun Chang, Ki Hyun Park, Ji Won Min, Eun Jeong Ko, Hyeyoung Lee, Chul Woo Yang, Byung Ha Chung, Eun-Jee Oh
Korean J Intern Med. 2021;36(1):164-174. Published online April 3, 2020
Background/Aims: To investigate if BK virus (BKV)-specific T cell immunity measured by an interferon-γ enzyme-linked immunospot (ELISPOT) assay can predict the outcome of BK virus infection in kidney transplant recipients (KTRs). Methods: We included 68 KTRs with different viremia status (no virem..
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Characteristics of kidney transplantation recipients over time in South Korea
Sehoon Park, Myoungsuk Kim, Ji Eun Kim, Kwangsoo Kim, Minsu Park, Yong Chul Kim, Kwon Wook Joo, Yon Su Kim, Hajeong Lee
Korean J Intern Med. 2020;35(6):1457-1467. Published online March 30, 2020
Background/Aims: Detailed nationwide information regarding the recent status and time trends of kidney transplantation (KT) in South Korea is limited.
Methods: We performed a nationwide, population-based cohort study using the national claims database of Korea. We included KT recipients from 2008 t..
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Renal effects of uric acid: hyperuricemia and hypouricemia
Jung Hwan Park, Yong-Il Jo, Jong-Ho Lee
Korean J Intern Med. 2020;35(6):1291-1304. Published online September 9, 2020
The prevalence of chronic kidney disease (CKD) is increasing worldwide. Although hyperuricemia has been associated with CKD in many studies, it remains controversial whether this is the cause or the result of decreased renal function. Recent observational studies of healthy populations and patients ..
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Nutritional management in patients with chronic kidney disease
Sun Moon Kim, Ji Yong Jung
Korean J Intern Med. 2020;35(6):1279-1290. Published online September 23, 2020
The global prevalence of chronic kidney disease (CKD) is increasing with the aging of populations worldwide. As kidney function declines, the accumulation of metabolic waste products and excessive electrolytes can significantly impair the health of patients with CKD. As nutritional management of pat..
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Hemato-oncology
Cancer incidence according to the National Health Information Database in Korean patients with end-stage renal disease receiving hemodialysis
Jisun Myung, Jung Hye Choi, Joo Hark Yi, Inah Kim
Korean J Intern Med. 2020;35(5):1210-1219. Published online February 20, 2020
Background/Aims: The aim of this study was to investigate incidence, survival, and risk factors of cancer in end-stage renal disease (ESRD) patients with hemodialysis using information from the National Health Information Database (NHID).
Methods: Using the NHID, we identified ESRD patients who sta..
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Nephrology
Urinary tissue inhibitor of metalloproteinase-2 and insulin-like growth factor-binding protein 7 as biomarkers of patients with established acute kidney injury
Won Yong Cho, Sung Yoon Lim, Ji Hyun Yang, Se Won Oh, Myung-Gyu Kim, Sang-Kyung Jo
Korean J Intern Med. 2020;35(3):662-671. Published online December 23, 2019
Background/Aims: Urinary tissue inhibitor of metalloproteinase-2 (TIMP-2) and insulin-like growth factor-binding protein 7 (IGFBP7) have been recently discovered and validated as sensitive biomarkers that can predict stage 2 or 3 acute kidney injury (AKI) development in high-risk patients. We aimed ..
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Infectious diseases
Diagnostic usefulness of the cytomegalovirus (CMV)-specific T cell-based assay for predicting CMV infection after kidney transplant
Taeeun Kim, Hyun-Jeong Lee, Sun-Mi Kim, Joo Hee Jung, Sung Shin, Young-Hoon Kim, Heungsup Sung, Yong Pil Chong, Sang-Oh Lee, Sang-Ho Choi, Yang Soo Kim, Jun Hee Woo, Sung-Han Kim, Duck Jong Han
Korean J Intern Med. 2020;35(2):438-448. Published online June 7, 2018
Background/Aims: We evaluated the usefulness in kidney transplant (KT) candidates of cytomegalovirus (CMV)-specific enzyme-linked immunospot (ELISPOT) assays for predicting the development of post-transplant CMV infections.
Methods: All adult recipients admitted for living-donor KT between March 20..
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Nephrology
Continuous renal replacement therapy in elderly with acute kidney injury
[corrected-article]
Kristianne Rachel P. Medina-Liabres, Sejoong Kim
Korean J Intern Med. 2020;35(2):284-294. Published online February 28, 2020
The objective of this article is to raise awareness among physicians of the increasing incidence of acute kidney injury in the elderly population and the utility of continuous renal replacement therapy (CRRT) in its management. While CRRT is frequently applied in younger patients, its use in elderly..
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Optimal blood pressure target and measurement in patients with chronic kidney disease
Chang Seong Kim, Hong Sang Choi, Eun Hui Bae, Soo Wan Kim, Seong Kwon Ma
Korean J Intern Med. 2019;34(6):1181-1187. Published online June 17, 2019
The prevalence rates of hypertension and chronic kidney disease (CKD) are increasing with the aging of the population. Hypertension and CKD are closely related, and hypertension with accompanying CKD is difficult to control. This difficulty controlling blood pressure (BP) can be explained by changes..
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Nephrology
Circulating renalase predicts all-cause mortality and renal outcomes in patients with advanced chronic kidney disease
Seon Ha Baek, Ran-hui Cha, Shin Wook Kang, Cheol Whee Park, Dae Ryong Cha, Sung Gyun Kim, Sun Ae Yoon, Sejoong Kim, Sang-Youb Han, Jung Hwan Park, Jae Hyun Chang, Chun Soo Lim, Yon Su Kim, Ki Young Na
Korean J Intern Med. 2019;34(4):858-866. Published online November 29, 2017
Background/Aims: Patients with chronic kidney disease (CKD) have been found to show markedly increased rates of end-stage renal disease, major adverse cardiovascular and cerebrovascular events (MACCEs), and mortality. Therefore, new biomarkers are required for the early detection of such clinical ou..
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Impact of sarcopenia on long-term mortality and cardiovascular events in patients undergoing hemodialysis
Jwa-Kyung Kim, Sung Gyun Kim, Ji-Eun Oh, Young-Ki Lee, Jung-Woo Noh, Hyung Jik Kim, Young Rim Song
Korean J Intern Med. 2019;34(3):599-607. Published online November 23, 2017
Background/Aims: A high body mass index (BMI) is known to correlate with better survival in patients on hemodialysis (HD). However, the impacts of body composition and sarcopenia on survival have not been well studied in this population.
Methods: One hundred and forty-two prevalent HD patients were..
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Cardiology
Extracellular vesicles in renal physiology and clinical applications for renal disease
Soon Hyo Kwon
Korean J Intern Med. 2019;34(3):470-479. Published online April 30, 2019
Many cells in the nephron release extracellular vesicles (EVs). EVs envelop nucleic acids, proteins, and lipids. The surfaces of EVs express donor cell-specific markers, ligands, and major histocompatibility complex molecules. They are involved in cell-to-cell communication, immune modulation, and t..
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Nephrology
Usefulness of valacyclovir prophylaxis for cytomegalovirus infection after anti-thymocyte globulin as rejection therapy
Eun Jeong Ko, Ji Hyun Yu, Chul Woo Yang, Byung Ha Chung
Korean J Intern Med. 2019;34(2):375-382. Published online December 15, 2017
Background/Aims: Anti-thymocyte globulin (ATG) treatment for acute T-cell mediated rejection (TCMR) can increase the risk of cytomegalovirus (CMV) infection. We aimed to evaluate the effect of valacyclovir prophylaxis against CMV infection after ATG administration as anti-rejection therapy.
Methods..
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Clinical significance of Th17 cells in kidney transplantation
Byung Ha Chung, Chul Woo Yang, Mi-La Cho
Korean J Intern Med. 2018;33(5):860-866. Published online May 31, 2018
Transplantation research has focused on cytotoxic T-cell and plasma cell/B-cell-targeted strategies, but little attention has been paid to the role of T helper 17 (Th17) cells in allograft dysfunction. However, accumulating evidence suggests that Th17 cells contribute to the development of acute and..
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Notch signaling in the collecting duct regulates renal tubulointerstitial fibrosis induced by unilateral ureteral obstruction in mice
Arum Choi, Sun Ah Nam, Wan-Young Kim, Sang Hee Park, Hyang Kim, Chul Woo Yang, Jin Kim, Yong Kyun Kim
Korean J Intern Med. 2018;33(4):774-782. Published online May 26, 2017
Background/Aims: Mind bomb-1 (Mib1) encodes an E3 ubiquitin ligase, which is required for the initiation of Notch signaling. Recently, it was demonstrated that the renal collecting duct plays an important role in renal fibrosis. Here, we investigated the role of Notch signaling in renal fibro..
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Hepatitis C virus infection in chronic kidney disease: paradigm shift in management
So Mi Kim, Il Han Song
Korean J Intern Med. 2018;33(4):670-678. Published online June 28, 2018
Hepatitis C virus (HCV) infection in chronic kidney disease (CKD) is associated with increased liver-related morbidity and mortality rates, accelerated progression to end-stage renal disease, and risk of cardiovascular events. CKD patients with HCV infection require antiviral therapy. Pegylated inte..
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Applications of kidney organoids derived from human pluripotent stem cells
Yong Kyun Kim, Sun Ah Nam, Chul Woo Yang
Korean J Intern Med. 2018;33(4):649-659. Published online June 28, 2018
The establishment of protocols to differentiate kidney organoids from human pluripotent stem cells provides potential applications of kidney organoids in regenerative medicine. Modeling of renal diseases, drug screening, nephrotoxicity testing of compounds, and regenerative therapy are attractive ap..
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Effects of colchicine on renal fibrosis and apoptosis in obstructed kidneys
Sejoong Kim, Eun Sook Jung, Jeonghwan Lee, Nam Ju Heo, Ki Young Na, Jin Suk Han
Korean J Intern Med. 2018;33(3):568-576. Published online March 18, 2017
Background/Aims: Colchicine is an established drug for microtubule stabilization that may reduce tissue injury. No data were available that its effects may depend on the dosage of colchicine. We investigated the anti-fibrotic and apoptotic effects of various dose of colchicine in a unilateral urete..
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Outcomes of living donor kidney transplantation in diabetic patients: age and sex matched comparison with non-diabetic patients
Chung Hee Baek, Hyosang Kim, Seung Don Baek, Mun Jang, Wonhak Kim, Won Seok Yang, Duck Jong Han, Su-Kil Park
Korean J Intern Med. 2018;33(2):356-366. Published online August 21, 2017
Background/Aims: Kidney transplantation (KT) reportedly provides a significant survival advantage over dialysis in diabetic patients. However, KT outcome in diabetic patients compared with that in non-diabetic patients remains controversial. In addition, owing to recent improvements in the outcomes ..
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Clinical significance of the presence of anti-human leukocyte antigen-donor specific antibody
in kidney transplant recipients with allograft dysfunction
Byung Ha Chung, Jeong Ho Kim, Bum Soon Choi, Cheol Whee Park, Ji-Il Kim, In Sung Moon, Yong-Soo Kim, Yeong Jin Choi, Eun-Jee Oh, Chul Woo Yang
Korean J Intern Med. 2018;33(1):157-167. Published online October 20, 2016
Background/Aims: This study investigated the clinical significance of detecting anti-human leukocyte antigen-donor specific antibody (HLA-DSA) in kidney transplant recipients (KTRs) requiring indication biopsy owing to allograft dysfunction.
Methods: We analyzed the presence of HLA-DSA in 210 KTRs ..
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